Get up to speed with these FAQs

Have questions about SILIQ? Take a look at some frequently asked questions and answers below. Of course, none of this replaces the advice of your healthcare provider. So be sure to ask him or her on your next visit.


  • What is SILIQ?
    • SILIQ is a prescription medicine for adults with moderate to severe psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet, or UV, light) and who have tried another systemic therapy that didn’t work or stopped working.
    • SILIQ works differently than other psoriasis medicines by blocking IL-17 Receptor A, a protein that contributes to psoriasis.
  • How do I take SILIQ?
    • SILIQ is given as an injection under the skin (known as subcutaneous, or SC, injection). SILIQ starts with 1 injection each week for the first 3 doses. Then after that, it is just 1 dose every 2 weeks.
    • If your doctor decides that you or a caregiver can give the injections at home, you will need to be trained on the right way to inject SILIQ. Your healthcare provider will take you through the steps to prepare, inject, and dispose of SILIQ. Do not try to inject SILIQ before this training. You'll also need to read the Medication Guide and Instructions for Use that come with your prescription before using SILIQ. Additionally, refer to our administration video.
  • How do I get SILIQ?
    • SILIQ is available by prescription through your healthcare provider. Your healthcare provider will work with you and your insurance company to get SILIQ approved. They will also work with a specialty pharmacy that will coordinate the process of getting SILIQ shipped to your home.
    • SILIQ is available through a restricted program (Risk Evaluation and Mitigation Strategy program, or REMS) because of observed suicidal behavior in clinical studies. You will need to sign a Prescriber-Patient Agreement Form and your healthcare provider will give you a SILIQ patient/wallet card about symptoms that need medical attention right away. Carry the card with you during treatment with SILIQ and show it to all of your healthcare providers. See below Important Safety Information for more information about the SILIQ REMS.
  • What is Siliq Solutions™?
    • Siliq Solutions is a support program designed for people taking SILIQ. Siliq Solutions includes a support team that can answer your questions about everything from injecting SILIQ to insurance and cost savings opportunities.
  • What is a specialty pharmacy?
    • A specialty pharmacy coordinates delivery of medications and provides support for patients taking medications like SILIQ. Your healthcare provider will work with a specialty pharmacy to get SILIQ approved with your insurance provider and to get it shipped to you.
  • What should I do if I miss a dose?
    • Please contact your healthcare provider if you miss a dose.
  • How do I store SILIQ?
    • Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton.
    • For convenience, prefilled syringes can be stored at room temperature up to a maximum of 77°F (25°C) in the original carton for a maximum single period of 14 days with protection from light and sources of heat. Once the prefilled syringe has reached room temperature, it should not be placed back into the refrigerator. If not used within 14 days at room temperature, discard the unused prefilled syringe in a sharps container and call your healthcare provider.
    • Keep in original carton to protect from light and physical damage during storage.
  • What is a specialty pharmacy?
    • A specialty pharmacy coordinates delivery of medications and provides support for patients taking medications like SILIQ. Your healthcare provider will work with a specialty pharmacy to get SILIQ approved with your insurance provider and to get it shipped to you.
  • What are the side effects of SILIQ?
    • The most common side effects of SILIQ include joint pain, headache, tiredness, diarrhea, mouth or throat pain, nausea, muscle pain, injection site reactions, flu, low white blood cell count (neutropenia), and fungal infections of the skin. Contact your healthcare professional if you experience any of these.
  • What is the most important information I should know about SILIQ?
    • Suicidal thoughts or behavior: Some patients taking SILIQ have had suicidal thoughts or ended their own lives. This risk is higher if you have a history of suicidal thoughts or depression. It is not known if SILIQ causes these thoughts or actions. Get medical help right away if you or a family member notices that you have any of the following symptoms:
      • new or worsening depression, anxiety, or mood problems
      • thoughts of suicide, dying, or hurting yourself
      • attempt to commit suicide or acting on dangerous impulses
      • other unusual changes in your behavior or mood
    • Your healthcare provider will give you a SILIQ patient/wallet card about symptoms that need medical attention right away. Carry the card with you during treatment with SILIQ and show it to all of your healthcare providers.
    • Serious Infections: SILIQ may lower the ability of your immune system to fight infections and may increase your risk of infections.
      • Your healthcare provider should check you for tuberculosis (TB) before starting treatment with SILIQ and may treat you for TB before starting SILIQ if you have TB or a history of it
      • You and your healthcare provider need to watch closely for signs and symptoms of infection during treatment with SILIQ, including fever, sweats, chills, shortness of breath, stomach issues, muscle aches, cough, sore throat or trouble swallowing, warm/red/painful skin sores, burning while urinating or more frequent urination
  • Who should not take SILIQ?
    • Do not use SILIQ if you have Crohn’s disease. Tell your healthcare provider if you develop diarrhea, bloody stools, stomach pain or cramping, sudden or uncontrollable bowel movements, loss of appetite, constipation, weight loss, fever or tiredness as these may be symptoms of Crohn’s disease.
  • How do I dispose of the needles and syringes?
    • You should dispose of your injection materials in a sharps container. Sharps containers are available from the specialty pharmacy that will ship SILIQ to you. Your specialty pharmacy will provide instructions on how to return the filled container and how to get a new one when needed.
  • Is SILIQ covered by insurance?
    • Your healthcare provider will work with you and your insurance company and specialty pharmacy to determine if you have coverage for SILIQ.
  • What can I do if my insurance doesn’t cover SILIQ?
    • Siliq Solutions will work to make sure every opportunity for coverage is explored and will assist your healthcare provider in appealing the decision if coverage is denied.
  • How much will SILIQ cost?
    • If you’re eligible, the SILIQ Instant Savings program* can help pay for SILIQ. If your insurance covers SILIQ, you will pay $5 per month for the first 12 months of SILIQ. If your commercial insurance doesn’t cover SILIQ, you will pay $25 per month for the first 12 months of SILIQ.

Indication and Important Safety Information

What is SILIQ?

SILIQ™ injection is a prescription medicine used to treat adults with moderate to severe plaque psoriasis:

  • who may benefit from injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light treatment) and
  • who have tried another systemic therapy that didn’t work or stopped working

It is not known if SILIQ is safe and effective in children.

What is the most important information I should know about SILIQ?

Suicidal thoughts or behavior: Some patients taking SILIQ have had suicidal thoughts or ended their own lives. This risk is higher if you have a history of suicidal thoughts or depression. It is not known if SILIQ causes these thoughts or actions. Get medical help right away if you or a family member notices that you have any of the following symptoms:

  • new or worsening depression, anxiety, or mood problems
  • thoughts of suicide, dying, or hurting yourself
  • attempt to commit suicide, or acting on dangerous impulses
  • other unusual changes in your behavior or mood

Your healthcare provider will give you a SILIQ patient/wallet card about symptoms that need medical attention right away. Carry the card with you during treatment with SILIQ and show it to all of your healthcare providers.

Serious Infections: SILIQ may lower the ability of your immune system to fight infections and may increase your risk of infections.

  • Your healthcare provider should check you for tuberculosis (TB) before starting treatment with SILIQ and may treat you for TB before starting SILIQ if you have TB or a history of it
  • You and your healthcare provider need to watch closely for signs and symptoms of infection during treatment with SILIQ, including fever, sweats, chills, shortness of breath, stomach issues, muscle aches, cough, sore throat or trouble swallowing, warm/red/painful skin sores, burning while urinating or more frequent urination

Who should not use SILIQ?

Do not use SILIQ if you have Crohn’s disease. Tell your healthcare provider if you develop diarrhea, bloody stools, stomach pain or cramping, sudden or uncontrollable bowel movements, loss of appetite, constipation, weight loss, fever or tiredness as these may be symptoms of Crohn’s disease.

Before starting SILIQ, tell your healthcare provider if you:

  • have a history of mental health problems, including suicidal thoughts, depression, anxiety, or mood problems
  • have an infection that does not go away or keeps coming back
  • have TB or have been in close contact with someone with TB
  • have recently received or are scheduled to receive an immunization (vaccine). You should avoid getting live vaccines while being treated with SILIQ
  • are or plan to become pregnant, or are breastfeeding or plan to do so. It is unknown if SILIQ can harm your unborn or newborn baby

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use SILIQ?

See the detailed “Instructions for Use” that come with your SILIQ for information on the right way to store, prepare, and give your SILIQ injections at home, and how to properly throw away (dispose of) used SILIQ prefilled syringes. Use SILIQ exactly as your healthcare provider tells you to use it.

What are possible side effects of SILIQ?

SILIQ may cause serious side effects. See “What is the most important information I should know about SILIQ?” and “Who should not take SILIQ?”

The most common side effects of SILIQ include:

  • Joint pain
  • Headache
  • Tiredness
  • Diarrhea
  • Mouth or throat pain
  • Nausea
  • Muscle pain
  • Injection site reactions
  • Flu
  • Low white blood cell count
  • (neutropenia)
  • Fungal infections of the skin

Call your doctor for medical advice on side effects. You are encouraged to report negative side effects of prescription drugs to FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Click here for full Prescribing Information, including Boxed Warning about suicidal ideation and behavior, and Medication Guide.

*Only patients meeting the eligibility criteria, including specified household income thresholds and residency requirements, can participate in the SILIQ Patient Assistance Program. Click here for full eligibility terms and conditions.

*This offer is only valid for patients with commercial insurance. Patients whose commercial insurance does not cover SILIQ will pay more. These savings offers are not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B and D Plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. Click here for full eligibility terms and conditions.

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Indication and Important Safety Information

What is SILIQ?

SILIQ™ injection is a prescription medicine used to treat adults with moderate to severe plaque psoriasis:

  • who may benefit from injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light treatment) and
  • who have tried another systemic therapy that didn’t work or stopped working

It is not known if SILIQ is safe and effective in children.

What is the most important information I should know about SILIQ?

Suicidal thoughts or behavior: Some patients taking SILIQ have had suicidal thoughts or ended their own lives. This risk is higher if you have a history of suicidal thoughts or depression. It is not known if SILIQ causes these thoughts or actions. Get medical help right away if you or a family member notices that you have any of the following symptoms:

  • new or worsening depression, anxiety, or mood problems
  • thoughts of suicide, dying, or hurting yourself
  • attempt to commit suicide, or acting on dangerous impulses
  • other unusual changes in your behavior or mood

Your healthcare provider will give you a SILIQ patient/wallet card about symptoms that need medical attention right away. Carry the card with you during treatment with SILIQ and show it to all of your healthcare providers.

Serious Infections: SILIQ may lower the ability of your immune system to fight infections and may increase your risk of infections.

  • Your healthcare provider should check you for tuberculosis (TB) before starting treatment with SILIQ and may treat you for TB before starting SILIQ if you have TB or a history of it
  • You and your healthcare provider need to watch closely for signs and symptoms of infection during treatment with SILIQ, including fever, sweats, chills, shortness of breath, stomach issues, muscle aches, cough, sore throat or trouble swallowing, warm/red/painful skin sores, burning while urinating or more frequent urination

Who should not use SILIQ?

Do not use SILIQ if you have Crohn’s disease. Tell your healthcare provider if you develop diarrhea, bloody stools, stomach pain or cramping, sudden or uncontrollable bowel movements, loss of appetite, constipation, weight loss, fever or tiredness as these may be symptoms of Crohn’s disease.

Before starting SILIQ, tell your healthcare provider if you:

  • have a history of mental health problems, including suicidal thoughts, depression, anxiety, or mood problems
  • have an infection that does not go away or keeps coming back
  • have TB or have been in close contact with someone with TB
  • have recently received or are scheduled to receive an immunization (vaccine). You should avoid getting live vaccines while being treated with SILIQ
  • are or plan to become pregnant, or are breastfeeding or plan to do so. It is unknown if SILIQ can harm your unborn or newborn baby

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use SILIQ?

See the detailed “Instructions for Use” that come with your SILIQ for information on the right way to store, prepare, and give your SILIQ injections at home, and how to properly throw away (dispose of) used SILIQ prefilled syringes. Use SILIQ exactly as your healthcare provider tells you to use it.

What are possible side effects of SILIQ?

SILIQ may cause serious side effects. See “What is the most important information I should know about SILIQ?” and “Who should not take SILIQ?”

The most common side effects of SILIQ include:

  • Joint pain
  • Headache
  • Tiredness
  • Diarrhea
  • Mouth or throat pain
  • Nausea
  • Muscle pain
  • Injection site reactions
  • Flu
  • Low white blood cell count
  • (neutropenia)
  • Fungal infections of the skin

Call your doctor for medical advice on side effects. You are encouraged to report negative side effects of prescription drugs to FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Click here for full Prescribing Information, including Boxed Warning about suicidal ideation and behavior, and Medication Guide.

*This offer is only valid for patients with commercial insurance. Patients whose commercial insurance does not cover SILIQ will pay more. These savings offers are not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B and D Plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. Click here for full eligibility terms and conditions.